(Appetite stimulant, anti-emetic)
By Dr. Karen Burgess

Brand name and formulations

  • Remeron
  • Tablet, dissolvable tablet

What is Mirtazapine used for?
Mirtazapine is used to stimulate the appetite and prevent vomiting.

What is Mirtazapine?
Mirtazapine is a human antidepressant that works in the brain to increase norepinephrine and serotonin activity stimulating appetite centers in the brain as a side effect.

How is Mirtazapine given and what if a dose is missed?
Mirtazapine is typically prescribed for once daily dosing in dogs and a twice weekly dosing in cats. If a dose is missed and it is less than 12 hours late, go ahead and give missed dose. If it is within 12 hours of the next dose, skip a dose and resume regular schedule with next dose. If using dissolvable tablet formulation, place it under the tongue and hold mouth shut for several seconds. Follow with a swallow of water.

Are there any common adverse effects with the use of Mirtazapine?
Reported side effects include increased vocalization and affection in cats, drowsiness, and elevated heart rate.

Who should not take Mirtazapine?
Use with caution in patients that have heart disease. Patients with liver or kidney disease may require a lower dose.

What drugs should not be given with Mirtazapine?
Mirtazapine should not be used in pets that have taken selegiline or amitraz in the last fourteen days. Use with care in patients taking tramadol or fluoxetine.

What follow up is necessary with Mirtazapine use?
Withdrawal signs with discontinuation of mirtazapine can occur in humans after longterm use.